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Mitochondria kill themselves to protect neurons from an early death

Voluntary movements, like lifting your hand to wave, are executed through precise coordination between different brain areas. Sometimes, due to the loss of neurons in the brain, some individuals cannot coordinate such voluntary movements and are said to be suffering from a condition called ataxia. A type of ataxia, known as the spinocerebellar ataxia, involves the loss of neurons from the spinal cord and cerebellum. These brain areas are responsible for controlling movement and balance. Caused b

Study cautions about the use of designer receptors to control the brain

A small depression in the football field, invisible to the eye due to levelled grass, may have given you a foot twist twice. The third time, however, you evade it like a charm because your brain has been constructing a map of the field and alerts you about the danger. Tiny cells called neurons, with their long tails and fibrous fingers, link together to form pathways within the brain that help you learn about your surroundings. However, it is difficult to pick out a single pathway to understand

The Shadow of a curse: Somatic mutations may help predict acute myeloid leukemia

Although epigenetic changes associated with carcinogenesis may be a topic of interest for many cancer biologists, researchers at the Weill Cornell Medical College believe that these mutations may actually precede cancer by as long as nine years.

The genes that were mutated in patients that would suffer AML were DNMT3A, TET2 (both involved in DNA methylation, thus help in the regulation of gene expression) IDH family (IDH1 and IDH2 both involved in cellular metabolism) and the SR family of splic

New research illuminates the path to ultrasensitive biosensors

Like a magnet that helps in searching for a needle in a haystack, biologists use biosensors to detect minute concentrations of a specific molecule in a solution containing different molecules. These sensors contain an array of specially designed molecules called receptors that can bind to selected molecules. Some applications such as measuring trace quantities of DNA having a small mutation in a pool of other genes require highly sensitive biosensors.

In a new study, researchers from the Indian

Halting the growth of harmful bacteria through specially-designed sugars

Since the discovery of penicillin in 1928, antibiotics have been used to subdue bacterial infections. However, the rampant use of antibiotics has made some species of bacteria immune to their effects. Novel antibiotic strategies are needed to fight the increasing number of antibiotic-resistant bacteria. In a recent study, researchers from the Indian Institute of Technology Bombay (IIT Bombay) and Bowdoin College, Maine, USA, present a new method to target disease-causing bacteria by introducing